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More on Fever #1

Updated: Feb 17, 2021

Let’s talk a bit about some concepts and words regarding infection and fever. There is a range or temperatures that are necessary for cell to activate a signal to defend the organism. There is much study on different viruses and bacteria and their particular temperature needs to be killed or be disarmed. Infection itself is a tissue breach at the cellular level. This breach activates cytokines and prostaglandins, a cascade of mediators are triggered to alert the hypothalamus to respond by creating a fever. The amount of fever needed depends upon the germ itself.

Prostaglandins are lipids made onsite of infection. This is why we need cholesterol. They are hormonal in nature. And help control vessel dilation and response as well as many other functions,

The hypothalamus is the thermal regulatory center (prostaglandin E2) is needed to increase body temperature to a febrile temperature. It stokes the fire so the train has enough energy to get up the hill successfully.

WBC (white blood cells), neutrophils, T cells, B cells, lymphocytes fight the infection. They are the front line hand to hand combat personnel. They need the fever to be activated.

Their jobs are to resolve infection (or contain/control/stop the breach). This resolution is required to maintain homeostasis after an inflammatory response.

If those responses do not happen the body does not go back to normal.

The beginning of the fever activation programs the end of the incident or if there is an end (or not)

If the beginning is altered the end is interrupted and restoration cannot occur

When that happens there is a failure to resolve an acute infection and a chronic state is the result.

Some slides to help possibly help clarity

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